The DOPPS is a prospective cohort study of hemodialysis practices based on the collection of observational longitudinal data for a random sample of patients from dialysis facilities in a representative and random sample of units in twenty countries.
The samples of patients in each facility, and sample of facilities in each country, are designed to provide a reliable picture of practices and outcomes in each facility, and in each geographic area.
In view of differences in patient outcomes of mortality and morbidity by country and by dialysis unit, the study helps researchers:
The DOPPS has shown that regional survival differences in
mortality (particularly for the United States compared with Europe) were
largely explained by differences in facility vascular access use. US and European facilities with similar percentages of
fistula, graft, and catheter use have, on average, similar survival.
In recent years, with the Fistula First Initiative, there
has been a commendable increase in fistula use in the United States, whereas in
several other countries, fistula use has fallen and/or catheter use has risen
In recent years, DOPPS observes that dialysis session length
has shortened in the United States, whereas it has gotten longer in most other
DOPPS countries. By both standard and IV analyses, the DOPPS has found that
longer treatment time is associated with lower mortality in models adjusted for
Kt/V, ultrafiltration rate, and other characteristics.
According to the DOPPS, short dialysis session length is now one
of the key practice differences between the United States and other DOPPS
countries, and its implications merit attention from research and policy
Quality of Life and
the Patient Experience
In addition to quality of life being an important predictor
of mortality, it is also an important end-point in itself. Recent research on
the time it takes to recover from dialysis treatment shows a great deal of variation among patients –
some will recover in an hour or two but many others take all day to recover.
For those patients, three days of every week are completely wiped out, in terms
of any meaningful and enjoyable quality of life. This is a big issue for
patients, and we plan to do more work to address this experience.
The DOPPS is overseen by the DOPPS Steering Committee and investigators representing each of the DOPPS countries, and coordinated by the Arbor Research Collaborative for Health (Arbor Research). Research is guided by these investigators, as well as Task Forces of experts in different study areas.
To learn more about joining an investigator team or using DOPPS data, see Partner With Us.
Representing a panel of experts in nephrology in each of our DOPPS countries, Investigators provide country specific guidance for DOPPS researchers and data collectors. Country Investigators assist in facility recruitment, review and localize study questionnaires, and offer insight into ESRD issues pertaining to their respective countries.
Alex Disney, MD *
Peter Kerr, MD
Martin Gallagher, MD
Dr. Sumaya Al Ghareeb*
Dr. Ali Alaradi
Michel Jadoul, MD
Norbert H. Lameire, MD *
Raymond Vanholder, MD, PhD
Manish Sood, MD
Rita Suri, MD, Msc
Jean Ethier, MD*
David C. Mendelssohn, MD*
Li Zuo, MD – Beijing
Mei Wang, MD – Beijing
Fanfan Hou, MD, PhD – Guangzhou
Jiaqi Qian, MD – Shanghai
Nan Chen, MD – Shanghai
Yucheng Yan, MD, PhD – Shanghai
Christian Combe, MD
Luc Frimat, MD, PhD*
Fitsum Guebre-Egziabher, MD, PhD
Juergen Bommer, MD*
Werner Kleophas, MD
Elke Schaeffner, MD
Vittorio Andreucci, MD *
Francesco Locatelli, MD
Loreto Gesualdo, MD
Tadao Akizawa, MD, PhD
Masafumi Fukagawa, MD, PhD
Masaaki Inaba , MD, PhD
Masaomi Nangaku , MD, PhD
Kosaku Nitta, MD, PhD
Dr. Bassam Al Helal
Dr. Naser Alkandari
Dr. Ali Alsahow
Dr. Anas Alyousef
Mark R. Marshall, MD
Dr. Yacoub Al Maimani
Dr. Issa Alsalmi
Dr. Fadwa Al Ali
Dr. Abdulla Hamad
Dr. Anton Andrusev
Dr. Boris Bikbov
Dr. Natalia Tomilina
Dr. Alexander Zemchenkov
Dr. Saeed Al-Ghamdi
Dr. Mohammed Al Ghonaim
Dr. Jamal Al Wakeel
Dr. Fayez Hejaili
Dr. Ayman Karkar
Dr. Faissal Shaheen
José Miguel Cruz, MD*
Luis Piera, MD *
Joan Fort, MD, PhD
Patricia de Sequera, MD
Stefan Jacobson, MD
Anders Christensson, MD, PhD
Dr. Kenan Ateş
Dr. Tevfik Ecder
Dr. Gültekin Süleymanlar
United Arab Emirates
Dr. Ali Abdulkarim Al Obaidli
Dr. Mona Al Rukhaimi
Dr. Samra Abouchacra
Dr. Mohamed Hassan
Dr. Abdul Kareem Saleh
Roger Greenwood, MSc, MD, FRCP *
Hugh C. Rayner, MD, FRCP
Richard Fluck, MD
* Emeritus Country Investigator
The DOPPS team is also grateful for the service of the late Country Investigators: Erwin Hecking, MD, Germany; Fernando Valderrábano, MD, Spain; and Cengiz Utaş, MD, Turkey.
The DOPPS Steering Committee provides oversight for the study and guidance on the DOPPS research and publications. Members of the DSC represent major renal foundations, societies, and patient groups, as well as Arbor Research scientific leadership.
Bruce Robinson, MD, MSCE
Vice President, Research
DOPPS Principal Investigator
Anna Marti i Monros
European Dialysis and Transplant Nurses Association (EDTNA)
Ziad Massy, MD, PhD
European Dialysis and Transplant Association (EDTA)
Friedrich K. Port, MD, MS
Alfred Cheung, MD
American Society of Nephrology (ASN)
Bill Peckham, BS
Ron Pisoni, PhD, MS
Kerry Willis, PhD
National Kidney Foundation (NKF)
Nathan Levin, MD
International Society of Nephrology (ISN)
Tadao Akizawa, MD, PhD
Japanese Society for Dialysis Therapy (JSDT)
The project team members of the DOPPS Coordinating Center manage the daily operations of the DOPPS. Overseeing the data collection worldwide, project team members recruit new facilities and work to ensure successful data collection at participating facilities. The DOPPS CC team members also develop the study protocol, questionnaires, and instruments. Research requests and general study inquiries can be directed to the Arbor Research DOPPS CC at firstname.lastname@example.org.
Any data collection questions or requests can be submitted by email to the DOPPS staff at the following locations:
DMG Initiatives, Inc., Project Coordinator
Anna Marti Monros
EDTNA, Project Coordinator
J-DOPPS Coordinating Center
Kyowa Hakko Kirin Co., Ltd./ EP-PharmaLine Co., Ltd.
DOPPS Coordinating Center
Port FK, Robinson BM, McCullough KP, Morgenstern H. Predialysis blood pressure on survival in hemodialysis patients. Kidney Int 2017;91(3):755-756.
Port FK, Morgenstern H, Bieber BA, Karaboyas A, McCullough K, Tentori F, Pisoni RL, Robinson BM. Understanding associations of hemodialysis practices with clinical and patient-reported outcomes: Examples from the DOPPS. Nephrol Dial Transplant. 2017 Feb 11. [Epub ahead of print]
Karaboyas A, Zee J, Brunelli SM, Usvyat LA, Weiner DE, Maddux FW, Nissenson AR, Jadoul M, Locatelli F, Winkelmayer WC, Port FK, Robinson BM, Tentori F. Dialysate potassium, serum potassium, mortality, and arrhythmia events in hemodialysis: Results from the DOPPS. Am J Kidney Dis 2017;69(2):266-277.
The DOPPS has published over 150 peer-reviewed papers. To search publications on dialysis outcomes and practice patterns, please click here.